FIP200 Antikörper

Produktnummer ABIN7118327

Der Kaninchen Polyklonal Anti-FIP200-Antikörper wurde für WB, ELISA, IHC, IF und IP validiert. Er ist geeignet, FIP200 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für FIP200 Antikörper (ABIN7118327)

Target: FIP200 (RB1CC1) (RB1-Inducible Coiled-Coil 1 (RB1CC1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FIP200 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Produktdetails anti-FIP200 Antikörper

Verwendungszweck: RB1CC1 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1480-1594

Immunogen: RB1-inducible coiled-coil 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:1000-1:6000, IP:1:500-1:1000, IHC: 1:20-1:200, IF: 1:10-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu FIP200

Target: FIP200 (RB1CC1) (RB1-Inducible Coiled-Coil 1 (RB1CC1))

Andere Bezeichnung: RB1CC1

Hintergrund:

Synonyms: RB1-inducible coiled-coil protein 1|FAK family kinase-interacting protein of 200 kDa (FIP200)|RB1CC1|KIAA0203|RBICC

Background: Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole(SCV) duting S.typhimurium infection and subsequent xenophagy. Autophagy positively regulates repair of DNA damage induced by ionizing radiation and negatively regulates apoptosis. Plays an indispensible role in fetal hematopoiesis and in the regulation of neuronal homeostasis(By similarity). Implicated in the regulation of RB1 expression. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway and a mediator that plays a crucial role in muscular differentiation. Expression is, thus, a prerequisite for myogenic differentiation. Inhibits PTK2/FAK1 and PTK2B/PYK2 activity and activation of downstream signaling pathways.

Molekulargewicht: 200 kDa

Gen-ID: 9821

UniProt: Q8TDY2

Pathways: Regulation of Cell Size, Autophagie