PA2G4 Antikörper

Produktnummer ABIN7117813

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PA2G4 in WB, ELISA, IHC, IF und FACS. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für PA2G4 Antikörper (ABIN7117813)

Target: PA2G4 (Proliferation-Associated 2G4, 38kDa (PA2G4))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PA2G4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-PA2G4 Antikörper

Verwendungszweck: PA2G4 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: proliferation-associated 2G4, 38kDa

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu PA2G4

Target: PA2G4 (Proliferation-Associated 2G4, 38kDa (PA2G4))

Andere Bezeichnung: PA2G4

Hintergrund:

Synonyms: Proliferation-associated protein 2G4|Cell cycle protein p38-2G4 homolog (hG4-1)|ErbB3-binding protein 1|PA2G4|EBP1

Background: May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor(AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin(HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase(HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs(internal ribosomal entry site)(By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation(By similarity).

Molekulargewicht: 42 kDa, 48 kDa

Gen-ID: 5036

UniProt: Q9UQ80

Pathways: Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Toll-Like Receptors Cascades