PHF2 Antikörper
Kurzübersicht für PHF2 Antikörper (ABIN7117376)
Target
Alle PHF2 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Verwendungszweck
- PHF2 antibody
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Aufreinigung
- Immunogen affinity purified
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Reinheit
- ≥95 % as determined by SDS-PAGE
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Immunogen
- PHD finger protein 2
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Isotyp
- IgG
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Applikationshinweise
- WB: 1:200-1:1000, IP: 1:500-1:1000, IHC: 1:20-1:200
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handhabung
- Avoid repeated freeze / thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- -20°C for 12 months
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Haltbarkeit
- 12 months
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- PHF2 (PHD Finger Protein 2 (PHF2))
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Andere Bezeichnung
- PHF2
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Hintergrund
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Synonyms: Lysine-specific demethylase PHF2|GRC5|PHD finger protein 2|PHF2|CENP-35|KIAA0662
Background: Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3(H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3(H3K4me3) at rDNA promoters and promotes expression of rDNA.
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Molekulargewicht
- 100 kDa, 150 kDa
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Gen-ID
- 5253
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UniProt
- O75151
Target
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