MMP2 Antikörper (AA 401-500)

Produktnummer ABIN707426

Der Kaninchen Polyklonal Anti-MMP2-Antikörper wurde für WB, ELISA, FACS, IHC (p), IF (cc), IF (p) und IHC (fro) validiert. Er ist geeignet, MMP2 in Proben von Human, Ratte, Maus und Kaninchen zu detektieren. Es sind 10+ Publikationen verfügbar.

Kurzübersicht für MMP2 Antikörper (AA 401-500) (ABIN707426)

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Reaktivität: Human, Ratte, Maus, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MMP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-MMP2 Antikörper

Bindungsspezifität: AA 401-500

Kreuzreaktivität: Human, Maus, Kaninchen, Ratte

Homologie: Cow,Sheep,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MMP-2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-MMP2 Antikörper (ABIN707426)

Bi, Zhang, Du, Zhang, Deng, Liu, Zhang: "Peripheral serotonin regulates postoperative intra-abdominal adhesion formation in mice." in: Scientific reports, Vol. 7, Issue 1, pp. 10001, (2019) (PubMed).

Gasparski, Ozarkar, Beningo: "Transient mechanical strain promotes the maturation of invadopodia and enhances cancer cell invasion in vitro." in: Journal of cell science, Vol. 130, Issue 11, pp. 1965-1978, (2018) (PubMed).

Wang, Nikhil, Viccaro, Chang, White, Shah: "Phosphorylation-dependent regulation of ALDH1A1 by Aurora kinase A: insights on their synergistic relationship in pancreatic cancer." in: BMC biology, Vol. 15, Issue 1, pp. 10, (2017) (PubMed).

Wang, Nikhil, Viccaro, Chang, Jacobsen, Sandusky, Shah: "The Aurora-A-Twist1 axis promotes highly aggressive phenotypes in pancreatic carcinoma." in: Journal of cell science, Vol. 130, Issue 6, pp. 1078-1093, (2017) (PubMed).

Liu, Chi, Lu, Zhang, Yamakawa: "Reversion-inducing-cysteine-rich Protein with Kazal Motif Is Involved in Intimal Hyperplasia in Carotid Arteries: A New Insight in the Prevention of Restenosis after Vascular Angioplasty." in: Annals of vascular surgery, Vol. 29, Issue 6, pp. 1293-9, (2015) (PubMed).

Cavdar, Ozbal, Celik, Ergur, Guneli, Ural, Camsari, Guner: "The effects of alpha-lipoic acid on MMP-2 and MMP-9 activities in a rat renal ischemia and re-perfusion model." in: Biotechnic & histochemistry : official publication of the Biological Stain Commission, Vol. 89, Issue 4, pp. 304-14, (2014) (PubMed).

Fan, Han, Zhu, Zhang, Zhu: "Ultrasensitive photoelectrochemical immunoassay for matrix metalloproteinase-2 detection based on CdS:Mn/CdTe cosensitized TiO2 nanotubes and signal amplification of SiO2@Ab2 conjugates." in: Analytical chemistry, Vol. 86, Issue 24, pp. 12398-405, (2014) (PubMed).

Details zu MMP2

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Andere Bezeichnung: MMP-2

Hintergrund:

Synonyms: CLG4, MONA, CLG4A, MMP-2, TBE-1, MMP-II, 72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A, Matrix metalloproteinase-2, MMP2

Background: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels. Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.

Gen-ID: 4313

UniProt: P08253

Pathways: Activation of Innate immune Response