NCOA3 Antikörper

Produktnummer ABIN7116985

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch NCOA3 in WB, ELISA, IHC, IF und FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für NCOA3 Antikörper (ABIN7116985)

Target: NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NCOA3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-NCOA3 Antikörper

Verwendungszweck: NCOA3 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: nuclear receptor coactivator 3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu NCOA3

Target: NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))

Andere Bezeichnung: NCOA3

Hintergrund:

Synonyms: Nuclear receptor coactivator 3 (NCoA-3)|ACTR|Amplified in breast cancer 1 protein (AIB-1)|CBP-interacting protein (pCIP)|Class E basic helix-loop-helix protein 42 (bHLHe42)|Receptor-associated coactivator 3 (RAC-3)|Steroid receptor coactivator protein 3 (SRC-3)|Thyroid hormone receptor activator molecule 1 (TRAM-1)|NCOA3|AIB1|BHLHE42|RAC3|TRAM1

Background: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids(GR and ER), retinoids(RARs and RXRs), thyroid hormone(TRs), vitamin D3(VDR) and prostanoids(PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.

Molekulargewicht: 160 kDa

Gen-ID: 8202

UniProt: Q9Y6Q9

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha