Nischarin Antikörper

Produktnummer ABIN7116889

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch Nischarin in WB, IP und ELISA. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für Nischarin Antikörper (ABIN7116889)

Target: Nischarin (NISCH)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Nischarin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), ELISA

Produktdetails anti-Nischarin Antikörper

Verwendungszweck: NISCH antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: nischarin

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IP: 1:200-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu Nischarin

Target: Nischarin (NISCH)

Andere Bezeichnung: NISCH

Hintergrund:

Synonyms: Nischarin|Imidazoline receptor 1 (I-1, IR1)|Imidazoline receptor antisera-selected protein (hIRAS)|Imidazoline-1 receptor (I1R)|Imidazoline-1 receptor candidate protein (I-1 receptor candidate protein, I1R candidate protein)|NISCH|IRAS|KIAA0975

Background: Acts either as the functional imidazoline-1 receptor(I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla(RVLM) neurons that exhibited rilmenidine-evoked hypotension(By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons(By similarity). Acts as a modulator of Rac-regulated signal transduction pathways(By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity(By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation(By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation(By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells(By similarity). Inhibits lamellipodia formation, when overexpressed(By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.

Molekulargewicht: 190-200 kDa

Gen-ID: 11188

UniProt: Q9Y2I1