MICAL2 Antikörper

Produktnummer ABIN7116286

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch MICAL2 in ELISA, IHC und IF. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für MICAL2 Antikörper (ABIN7116286)

Target: MICAL2 (Microtubule Associated Monoxygenase, Calponin and LIM Domain Containing 2 (MICAL2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MICAL2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-MICAL2 Antikörper

Verwendungszweck: MICAL2 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: microtubule associated monoxygenase, calponin and LIM domain containing 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC: 1:20-1:200, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu MICAL2

Target: MICAL2 (Microtubule Associated Monoxygenase, Calponin and LIM Domain Containing 2 (MICAL2))

Andere Bezeichnung: MICAL2

Hintergrund:

Synonyms: [F-actin]-monooxygenase MICAL2|MICAL C-terminal-like protein (Mical-cL)|Molecule interacting with CasL protein 2 (MICAL-2)|MICAL2|KIAA0750|MICAL2PV1|MICAL2PV2|MICALCL

Background: Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.

Molekulargewicht: 95, 112 kDa

Gen-ID: 9645

UniProt: O94851