MICAL2 Antikörper

Produktnummer ABIN7116286

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MICAL2 in ELISA, IHC und IF. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für MICAL2 Antikörper (ABIN7116286)

Target: MICAL2 (Microtubule Associated Monoxygenase, Calponin and LIM Domain Containing 2 (MICAL2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MICAL2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-MICAL2 Antikörper

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: microtubule associated monoxygenase, calponin and LIM domain containing 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC: 1:20-1:200, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu MICAL2

Target: MICAL2 (Microtubule Associated Monoxygenase, Calponin and LIM Domain Containing 2 (MICAL2))

Andere Bezeichnung: MICAL2

Hintergrund: Synonyms:KIAA0750, MICAL2PV1, MICAL2PV2 Background:Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.

Molekulargewicht: 95, 112 kDa

Gen-ID: 9645

UniProt: O94851