MMP12 Antikörper
Kurzübersicht für MMP12 Antikörper (ABIN7116085)
Target
Alle MMP12 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Verwendungszweck
- MMP12 antibody
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Aufreinigung
- Immunogen affinity purified
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Reinheit
- ≥95 % as determined by SDS-PAGE
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Immunogen
- matrix metallopeptidase 12(macrophage elastase)
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Isotyp
- IgG
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Applikationshinweise
- WB: 1:500-1:1000, IHC: 1:20-1:200, IF: 1:10-1:100
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handhabung
- Avoid repeated freeze / thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- -20°C for 12 months
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Haltbarkeit
- 12 months
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- MMP12 (Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12))
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Andere Bezeichnung
- MMP12
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Hintergrund
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Synonyms: Macrophage metalloelastase (MME)|Macrophage elastase (ME, hME)|Matrix metalloproteinase-12 (MMP-12)|MMP12|HME
Background: MMP12(Matrix metalloproteinase-12) is a 54 kDa proenzyme that is processed into a 45 kDa and then a 22 kDa active form(15723202). MMP9 and MMP12 promote intimal thickening by independent cleavage of N-cadherin, which elevates vascular smooth muscle cell proliferation via beta-catenin signalling. Its overexpression in myeloid lineage cells plays a key role in modulating myelopoiesis, immune suppression, and lung tumorigenesis(PMID: 21378275).
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Molekulargewicht
- 54 kDa, 45 kDa
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Gen-ID
- 4321
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UniProt
- P39900
Target
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