INSIG1 Antikörper
Kurzübersicht für INSIG1 Antikörper (ABIN7115274)
Target
Alle INSIG1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Aufreinigung
- Immunogen affinity purified
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Reinheit
- ≥95 % as determined by SDS-PAGE
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Immunogen
- insulin induced gene 1
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Isotyp
- IgG
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anti-Insulin Induced Gene 1 (INSIG1) (AA 1-87) antibody
INSIG1 Reaktivität: Human WB, ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (Internal Region) antibodyINSIG1 Reaktivität: Human, Maus WB, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (AA 36-63), (N-Term) antibodyINSIG1 Reaktivität: Human WB, FACS, IHC (p) Wirt: Kaninchen Polyclonal RB21689 unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (AA 63-112) antibodyINSIG1 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Ziege, Pferd, Kaninchen, Hund, Meerschweinchen, Schwein, Affe, Hamster, Xenopus laevis, Fledermaus, Huhn WB, IHC, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (Middle Region) antibodyINSIG1 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Ziege, Pferd, Kaninchen, Hund, Meerschweinchen, Schaf, Zebrafisch (Danio rerio) WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (C-Term) antibodyINSIG1 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (AA 71-120) antibodyINSIG1 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Ziege, Pferd, Kaninchen, Schaf, Schwein, Hamster, Xenopus laevis WB Wirt: Kaninchen Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (C-Term) antibodyINSIG1 Reaktivität: Human, Affe WB Wirt: Kaninchen Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (Middle Region) antibodyINSIG1 Reaktivität: Human, Maus, Ratte WB Wirt: Kaninchen Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (Middle Region) antibodyINSIG1 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Ziege, Pferd, Kaninchen, Hund, Meerschweinchen, Schaf, Schwein, Zebrafisch (Danio rerio) WB Wirt: Kaninchen Polyclonal unconjugated
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Applikationshinweise
- WB: 1:500-1:2000, IHC: 1:20-1:200
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
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Haltbarkeit
- 12 months
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- INSIG1 (Insulin Induced Gene 1 (INSIG1))
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Andere Bezeichnung
- INSIG1
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Hintergrund
- Synonyms:CL 6, INSIG 1, INSIG1, insulin induced gene 1, Insulin induced gene 1 protein Background:Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins(SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation(ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.
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Molekulargewicht
- 28-31, 66-70 kDa
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Gen-ID
- 3638
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UniProt
- O15503
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Pathways
- ER-Nucleus Signaling
Target
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