IDO1 Antikörper

Produktnummer ABIN7115217

Dieses Anti-IDO1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von IDO1 in WB, ELISA und IHC. Geeignet für Human, Maus und Ratte.

Kurzübersicht für IDO1 Antikörper (ABIN7115217)

Target: IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IDO1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-IDO1 Antikörper

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: indoleamine 2,3-dioxygenase 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:1000-1:4000, IHC: 1:50-1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu IDO1

Target: IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))

Andere Bezeichnung: IDO1

Hintergrund: Synonyms:CD107B, IDO, IDO 1, IDO1, INDO, indoleamine 2,3 dioxygenase 1 Background:Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway(PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses(PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells(PubMed:25691885). Acts as a suppressor of anti-tumor immunity(PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan(PubMed:25691885). Protects the fetus from maternal immune rejection(PubMed:25691885).

Molekulargewicht: 42 kDa

Gen-ID: 3620

UniProt: P14902

Pathways: Activated T Cell Proliferation