Importin 4 Antikörper

Produktnummer ABIN7115210

Der Kaninchen Polyklonal Anti-Importin 4-Antikörper wurde für WB, IHC, ELISA, IF und IP validiert. Er ist geeignet, Importin 4 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für Importin 4 Antikörper (ABIN7115210)

Target: Importin 4 (IPO4)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Importin 4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Produktdetails anti-Importin 4 Antikörper

Verwendungszweck: IPO4 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: importin 4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu Importin 4

Target: Importin 4 (IPO4)

Andere Bezeichnung: IPO4

Hintergrund:

Synonyms: Importin-4 (Imp4)|Importin-4b (Imp4b)|Ran-binding protein 4 (RanBP4)|IPO4|IMP4B|RANBP4

Background: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals(NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex(NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus(By similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Molekulargewicht: 118 kDa

Gen-ID: 79711

UniProt: Q8TEX9

Pathways: Protein targeting to Nucleus