IKZF1 Antikörper
Kurzübersicht für IKZF1 Antikörper (ABIN7115178)
Target
Alle IKZF1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Verwendungszweck
- IKZF1 antibody
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Aufreinigung
- Immunogen affinity purified
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Reinheit
- ≥95 % as determined by SDS-PAGE
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Immunogen
- IKAROS family zinc finger 1(Ikaros)
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Isotyp
- IgG
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Applikationshinweise
- WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handhabung
- Avoid repeated freeze / thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- -20°C for 12 months
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Haltbarkeit
- 12 months
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- IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))
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Andere Bezeichnung
- IKZF1
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Hintergrund
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Synonyms: DNA-binding protein Ikaros|Ikaros family zinc finger protein 1|Lymphoid transcription factor LyF-1|IKZF1|IK1|IKAROS|LYF1|ZNFN1A1
Background: Transcription regulator of hematopoietic cell differentiation(PubMed:17934067). Binds gamma-satellite DNA(PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B-and T-cells. Binds and activates the enhancer(delta-A element) of the CD3-delta gene. Repressor of the TDT(fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF(SWI/SNF), in a single complex(PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells(RPCs)(By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms(PubMed:17135265, PubMed:17934067).
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Molekulargewicht
- 57-70 kDa
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Gen-ID
- 10320
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UniProt
- Q13422
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Pathways
- Production of Molecular Mediator of Immune Response
Target
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