GRP78 Antikörper

Produktnummer ABIN7114888

Dieses Maus Monoklonal-Antikörper erkennt spezifisch GRP78 in WB, ELISA, IHC und IF. Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.

Kurzübersicht für GRP78 Antikörper (ABIN7114888)

Target: GRP78 (HSPA5) (Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5))

Reaktivität: Human, Ratte, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GRP78 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Klon: 3F8

Produktdetails anti-GRP78 Antikörper

Verwendungszweck: HSPA5 antibody

Aufreinigung: Protein A+G purification

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: Endoplasmic reticulum chaperone BiP

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:2000-1:20000, IHC: 1:50-1:200, IF: 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu GRP78

Target: GRP78 (HSPA5) (Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5))

Andere Bezeichnung: HSPA5

Hintergrund:

Synonyms: Endoplasmic reticulum chaperone BiP|78 kDa glucose-regulated protein (GRP-78)|Binding-immunoglobulin protein (BiP)|Heat shock protein 70 family protein 5 (HSP70 family protein 5)|Heat shock protein family A member 5|Immunoglobulin heavy chain-binding protein|HSPA5|GRP78

Background: GRP78 (HSPA5), also referred to as 'immunoglobulin heavy chain-binding protein' (BiP), is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER).It is a constitutively expressed resident protein of the ER in all eukaryotic cells. Recently it has been reported that GRP78 is associated with apoptosis or inhibition of cancer cell growth.

Molekulargewicht: 70-78 kDa

UniProt: P11021

Pathways: Thyroid Hormone Synthesis, ER-Nucleus Signaling