FLT3 Antikörper
Kurzübersicht für FLT3 Antikörper (ABIN7114273)
Target
Alle FLT3 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Verwendungszweck
- FLT3 antibody
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Aufreinigung
- Immunogen affinity purified
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Reinheit
- ≥95 % as determined by SDS-PAGE
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Immunogen
- fms-related tyrosine kinase 3
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Isotyp
- IgG
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Applikationshinweise
- WB: 1:500-1:2000, IP: 1:200-1:2000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handhabung
- Avoid repeated freeze / thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- -20°C for 12 months
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Haltbarkeit
- 12 months
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- FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))
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Andere Bezeichnung
- FLT3
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Hintergrund
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Synonyms: Receptor-type tyrosine-protein kinase FLT3|FL cytokine receptor|Fetal liver kinase-2 (FLK-2)|Fms-like tyrosine kinase 3 (FLT-3)|Stem cell tyrosine kinase 1 (STK-1)|FLT3|CD135|FLK2|STK1
Background: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
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Molekulargewicht
- 130-140 kDa
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Gen-ID
- 2322
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UniProt
- P36888
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Pathways
- RTK Signalweg
Target
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