FBXO6 Antikörper

Produktnummer ABIN7114053

Dieses Anti-FBXO6-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von FBXO6 in WB, ELISA und IHC. Geeignet für Human, Maus und Ratte.

Kurzübersicht für FBXO6 Antikörper (ABIN7114053)

Target: FBXO6 (F-Box Protein 6 (FBXO6))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FBXO6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-FBXO6 Antikörper

Verwendungszweck: FBXO6 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: F-box protein 6

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu FBXO6

Target: FBXO6 (F-Box Protein 6 (FBXO6))

Andere Bezeichnung: FBXO6

Hintergrund:

Synonyms: F-box only protein 6|F-box protein that recognizes sugar chains 2|F-box/G-domain protein 2|FBXO6|FBG2|FBS2|FBX6

Background: Substrate-recognition component of some SCF(SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway(ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1(phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.

Molekulargewicht: 35 kDa

Gen-ID: 26270

UniProt: Q9NRD1