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FBXO6 Antikörper (AA 104-293)

FBXO6 Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7152447
  • Target Alle FBXO6 Antikörper anzeigen
    FBXO6 (F-Box Protein 6 (FBXO6))
    Bindungsspezifität
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 104-293
    Reaktivität
    • 12
    • 2
    • 2
    Human
    Wirt
    • 7
    • 4
    • 1
    Kaninchen
    Klonalität
    • 9
    • 3
    Polyklonal
    Konjugat
    • 12
    Dieser FBXO6 Antikörper ist unkonjugiert
    Applikation
    • 11
    • 5
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Kreuzreaktivität
    Human
    Aufreinigung
    Antigen Affinity Purified
    Immunogen
    Recombinant Human F-box only protein 6 protein (104-293AA)
    Isotyp
    IgG
  • Applikationshinweise
    Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    FBXO6 (F-Box Protein 6 (FBXO6))
    Andere Bezeichnung
    FBXO6 (FBXO6 Produkte)
    Synonyme
    FBG2 antikoerper, FBS2 antikoerper, FBX6 antikoerper, Fbx6b antikoerper, AA408845 antikoerper, Fbs2 antikoerper, Fbxo6b antikoerper, Fbg2 antikoerper, FBXO6 antikoerper, fbg2 antikoerper, fbs2 antikoerper, fbx6 antikoerper, fbx6b antikoerper, fbxo44 antikoerper, F-box protein 6 antikoerper, F-box protein 6 S homeolog antikoerper, FBXO6 antikoerper, Fbxo6 antikoerper, fbxo6.S antikoerper
    Hintergrund

    Background: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on \\\'Ser-345\\\'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.

    Aliases: F box protein that recognizes sugar chains 2 antibody, F box G domain protein 2 antibody, F box only protein 6 antibody, F box protein 6 antibody, F box protein FBG2 antibody, F box protein Fbx6 antibody, F box/G domain protein 2 antibody, F-box only protein 6 antibody, F-box protein that recognizes sugar chains 2 antibody, F-box/G-domain protein 2 antibody, FBG 2 antibody, FBG2 antibody, FBS 2 antibody, FBS2 antibody, FBX 6 antibody, FBX6 antibody, FBX6_HUMAN antibody, FBXO 6 antibody, FBXO6 antibody, OTTHUMP00000002267 antibody

    UniProt
    Q9NRD1
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