EIF2AK1 Antikörper (AA 1-194)

Produktnummer ABIN7113933

Dieses Anti-EIF2AK1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von EIF2AK1 in WB, ELISA und IHC. Geeignet für Human, Maus und Ratte.

Kurzübersicht für EIF2AK1 Antikörper (AA 1-194) (ABIN7113933)

Target: EIF2AK1 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EIF2AK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-EIF2AK1 Antikörper

Bindungsspezifität: AA 1-194

Verwendungszweck: EIF2AK1 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-194aa

Immunogen: eukaryotic translation initiation factor 2-alpha kinase 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu EIF2AK1

Target: EIF2AK1 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1))

Andere Bezeichnung: EIF2AK1

Hintergrund:

Synonyms: Eukaryotic translation initiation factor 2-alpha kinase 1|Heme-controlled repressor (HCR)|Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase|Heme-regulated inhibitor (hHRI)|Hemin-sensitive initiation factor 2-alpha kinase|EIF2AK1|HRI|KIAA1369

Background: Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells(RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties. Thus plays an essential protective role for RBC survival in anemias of iron deficiency. Similarly, in hepatocytes, involved in heme-mediated translational control of CYP2B and CYP3A and possibly other hepatic P450 cytochromes. May also contain ER stress during acute heme-deficient conditions(By similarity).

Molekulargewicht: 60-71 kDa

Gen-ID: 27102

UniProt: Q9BQI3

Pathways: Hepatitis C