EPH Receptor A8 Antikörper

Produktnummer ABIN7113851

Der Kaninchen Polyklonal Anti-EPH Receptor A8-Antikörper wurde für ELISA und WB validiert. Er ist geeignet, EPH Receptor A8 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für EPH Receptor A8 Antikörper (ABIN7113851)

Target: EPH Receptor A8 (EPHA8)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPH Receptor A8 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Produktdetails anti-EPH Receptor A8 Antikörper

Verwendungszweck: EPHA8 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: EPH receptor A8

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu EPH Receptor A8

Target: EPH Receptor A8 (EPHA8)

Andere Bezeichnung: EPHA8

Hintergrund:

Synonyms: Ephrin type-A receptor 8|EPH- and ELK-related kinase|EPH-like kinase 3 (EK3, hEK3)|Tyrosine-protein kinase receptor EEK|EPHA8|EEK|HEK3|KIAA1459

Background: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth(By similarity).

Molekulargewicht: 120 kDa

Gen-ID: 2046

UniProt: P29322

Pathways: RTK Signalweg