CLASP2 Antikörper

Produktnummer ABIN7113293

Der Kaninchen Polyklonal anti-CLASP2 Antikörper wird verwendet zum Nachweis von CLASP2 in Proben von Human, Maus und Ratte. Er wurde validiert für WB und ELISA.

Kurzübersicht für CLASP2 Antikörper (ABIN7113293)

Target: CLASP2 (Cytoplasmic Linker Associated Protein 2 (CLASP2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CLASP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-CLASP2 Antikörper

Verwendungszweck: CLASP2 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: cytoplasmic linker associated protein 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu CLASP2

Target: CLASP2 (Cytoplasmic Linker Associated Protein 2 (CLASP2))

Andere Bezeichnung: CLASP2

Hintergrund:

Synonyms: CLIP-associating protein 2|Cytoplasmic linker-associated protein 2|Protein Orbit homolog 2 (hOrbit2)|CLASP2|KIAA0627

Background: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules(PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network(TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2(PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle(PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.

Molekulargewicht: 140-160 kDa

Gen-ID: 23122

UniProt: O75122

Pathways: Microtubule Dynamics, Maintenance of Protein Location