Claspin Antikörper
Kurzübersicht für Claspin Antikörper (ABIN7112861)
Target
Alle Claspin (CLSPN) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Verwendungszweck
- CLSPN antibody
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Aufreinigung
- Immunogen affinity purified
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Reinheit
- ≥95 % as determined by SDS-PAGE
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Immunogen
- claspin homolog(Xenopus laevis)
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Isotyp
- IgG
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Applikationshinweise
- WB: 1:200-1:1000, IP: 1:500-1:2000, IF: 1:20-1:200
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handhabung
- Avoid repeated freeze / thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- -20°C for 12 months
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Haltbarkeit
- 12 months
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- Claspin (CLSPN)
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Andere Bezeichnung
- CLSPN
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Hintergrund
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Synonyms: Claspin (hClaspin)|CLSPN
Background: Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex(pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks.
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Molekulargewicht
- 240 kDa
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Gen-ID
- 63967
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UniProt
- Q9HAW4
Target
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