CEP63 Antikörper

Produktnummer ABIN7112613

Dieses Anti-CEP63-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CEP63 in WB, ELISA, IHC, IF und IP. Geeignet für Human, Maus und Ratte.

Kurzübersicht für CEP63 Antikörper (ABIN7112613)

Target: CEP63 (Centrosomal Protein 63kDa (CEP63))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CEP63 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Produktdetails anti-CEP63 Antikörper

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: centrosomal protein 63kDa

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu CEP63

Target: CEP63 (Centrosomal Protein 63kDa (CEP63))

Andere Bezeichnung: CEP63

Hintergrund: Synonyms: Background:Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication, the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152, however, this function has been questioned(PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes(PubMed:21406398). Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks(DSBs), is removed from centrosomes, this leads to the inactivation of spindle assembly and delay in mitotic progression(PubMed:21406398).

Molekulargewicht: 57-75kd

Gen-ID: 80254

UniProt: Q96MT8

Pathways: M Phase