CEP152 Antikörper

Produktnummer ABIN7112602

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch CEP152 in ELISA, WB und IP. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für CEP152 Antikörper (ABIN7112602)

Target: CEP152 (Centrosomal Protein 152kDa (CEP152))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CEP152 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunoprecipitation (IP)

Produktdetails anti-CEP152 Antikörper

Verwendungszweck: CEP152 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: centrosomal protein 152kDa

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IP: 1:200-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu CEP152

Target: CEP152 (Centrosomal Protein 152kDa (CEP152))

Andere Bezeichnung: CEP152

Hintergrund:

Synonyms: Centrosomal protein of 152 kDa (Cep152)|CEP152|KIAA0912

Background: Necessary for centrosome duplication, the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication(PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 Molecules involved in centriole formation(PubMed:21059844, PubMed:20852615). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure(PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles(By similarity). Overexpression of CEP152 can drive amplification of centrioles(PubMed:20852615).

Molekulargewicht: 110 kDa

Gen-ID: 22995

UniProt: O94986

Pathways: M Phase