PD-L1 Antikörper (AA 25-241)

Produktnummer ABIN7112475

Dieses Anti-PD-L1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von PD-L1 in WB, IHC, ELISA und IF. Geeignet für Human, Maus und Schwein.

Kurzübersicht für PD-L1 Antikörper (AA 25-241) (ABIN7112475)

Target: PD-L1 (CD274 (PD-L1))

Reaktivität: Human, Maus, Schwein

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PD-L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Klon: 6C11

Produktdetails anti-PD-L1 Antikörper

Bindungsspezifität: AA 25-241

Verwendungszweck: CD274 antibody

Aufreinigung: Protein A+G purification

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 25-241 aa

Immunogen: CD274 molecule

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:5000, IHC: 1:100-1:500, IF: 1:50-1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu PD-L1

Target: PD-L1 (CD274 (PD-L1))

Andere Bezeichnung: CD274

Hintergrund:

Synonyms: Programmed cell death 1 ligand 1 (PD-L1, PDCD1 ligand 1, Programmed death ligand 1, hPD-L1)|B7 homolog 1 (B7-H1)|CD274|B7H1|PDCD1L1|PDCD1LG1|PDL1

Background: Programmed cell death ligand 1(CD274, or B7-H1, PD-L1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. PD-L1 is a 290 aa transmembrane protein with a calculated molecular weight of 33 kDa, the apparent molecular weight has been reported as 45-70 kDa, suggesting probable glycosylation(PMID: 18760278, 16493058).?

Molekulargewicht: 40-50 kDa

Gen-ID: 29126

UniProt: Q9NZQ7

Pathways: Cancer Immune Checkpoints