BRD8 Antikörper (AA 530-920)

Produktnummer ABIN7112079

Dieses Anti-BRD8-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von BRD8 in WB, ELISA, IHC und IF. Geeignet für Human.

Kurzübersicht für BRD8 Antikörper (AA 530-920) (ABIN7112079)

Target: BRD8 (Bromodomain Containing 8 (BRD8))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BRD8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Klon: 4B2

Produktdetails anti-BRD8 Antikörper

Bindungsspezifität: AA 530-920

Verwendungszweck: BRD8 antibody

Aufreinigung: Protein A+G purification

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 530-920aa

Immunogen: bromodomain containing 8

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:50-1:500, IF: 1:50-1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu BRD8

Target: BRD8 (Bromodomain Containing 8 (BRD8))

Andere Bezeichnung: BRD8

Hintergrund:

Synonyms: Bromodomain-containing protein 8|Skeletal muscle abundant protein|Skeletal muscle abundant protein 2|Thyroid hormone receptor coactivating protein of 120 kDa (TrCP120)|p120|BRD8|SMAP|SMAP2

Background: May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors(NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase(HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

Molekulargewicht: 120 kDa

Gen-ID: 10902

UniProt: Q9H0E9