Liver Arginase Antikörper (AA 1-236)

Produktnummer ABIN7111710

Dieses Anti-Liver Arginase-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Liver Arginase in WB, ELISA, IHC und IF. Geeignet für Human, Ratte und Maus.

Kurzübersicht für Liver Arginase Antikörper (AA 1-236) (ABIN7111710)

Target: Liver Arginase (ARG1) (Arginase, Liver (ARG1))

Reaktivität: Human, Ratte, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Liver Arginase Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Klon: 4A0

Produktdetails anti-Liver Arginase Antikörper

Bindungsspezifität: AA 1-236

Verwendungszweck: ARG1 antibody

Aufreinigung: Protein A+G purification

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-236aa

Immunogen: arginase, liver

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: WB: 1:1000-1:8000, IHC: 1:200-1:1000, IF:1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu Liver Arginase

Target: Liver Arginase (ARG1) (Arginase, Liver (ARG1))

Andere Bezeichnung: ARG1

Hintergrund:

Synonyms: Arginase-1|Liver-type arginase|Type I arginase|ARG1

Background: Arginase-1(Liver arginase) belongs to the arginase family. ARG1 is a novel immunohistochemicalmarkerof hepatocellular differentiation in fine needle aspiration cytology and a markerof hepatocytes and hepatocellular neoplasms. ARG1 is closely associated with alternative macrophage activation(PMID:12098359) and ARG1 has been shown to protectmotor neurons from trophic factor deprivation and allow sensory neurons to overcome neurite outgrowth inhibition by myelin proteins(PMID: 20071539).It can exsit as a homotrimer(PMID:16141327) and it has 3 isoforms produced by alternative splicing.Defects in ARG1 are the cause of argininemia(ARGIN). Deletion or TNF-mediated restriction of ARG1 unleashes the production of NO by NOS2, which is critical for pathogen control.(PMID:27117406).

Molekulargewicht: 35 kDa

Gen-ID: 383

UniProt: P05089

Pathways: Cellular Response to Molecule of Bacterial Origin