MICA Antikörper (AA 24-307)
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- Target Alle MICA Antikörper anzeigen
- MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
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Bindungsspezifität
- AA 24-307
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Monoklonal
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Konjugat
- Dieser MICA Antikörper ist unkonjugiert
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Applikation
- ELISA, Flow Cytometry (FACS)
- Aufreinigung
- Purified from cell culture supernatant by affinity chromatography
- Immunogen
- Recombinant human MICA(Glu24-Trp307) (ABIN6964102) produced by using human HEK293 cells
- Klon
- DM157
- Isotyp
- IgG
- Top Product
- Discover our top product MICA Primärantikörper
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- Applikationshinweise
- ELISA 1/5000-10000,Flow Cyt 1/100
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Reconstitute with deionized water
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.,0.1 % Procline 300
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Haltbarkeit
- 12 months
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- Target
- MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
- Andere Bezeichnung
- MICA (MICA Produkte)
- Hintergrund
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Synonyms:MIC-A, PERB11.1
Description:This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014] - Molekulargewicht
- 42.9KDa
- Pathways
- Activation of Innate immune Response, Transition Metal Ion Homeostasis, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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