SUFUH Antikörper
-
- Target Alle SUFUH Antikörper anzeigen
- SUFUH (Suppressor of Fused Homolog (SUFUH))
-
Reaktivität
- Human
-
Wirt
- Maus
-
Klonalität
- Monoklonal
-
Konjugat
- Dieser SUFUH Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Homologie
- Human,Mouse,Monkey
- Immunogen
- Recombinant human SUFU.
- Klon
- D6S12
- Top Product
- Discover our top product SUFUH Primärantikörper
-
anti-Suppressor of Fused Homolog (SUFUH) (AA 325-484) antibody
SUFUH Reaktivität: Human WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (AA 325-484) antibodySUFUH Reaktivität: Human WB, IHC, ELISA Wirt: Kaninchen Polyclonal unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (AA 433-484) antibodySUFUH Reaktivität: Human, Maus, Ratte WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Suppressor of Fused Homolog (SUFUH) antibodySUFUH Reaktivität: Human, Maus, Green Monkey WB, IHC (p) Wirt: Maus Monoclonal 1783CT536-263-29 unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (AA 308-341), (C-Term) antibodySUFUH Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB53250 unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (AA 1-484) antibodySUFUH Reaktivität: Human WB, PLA Wirt: Kaninchen Polyclonal unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (AA 181-280) antibodySUFUH Reaktivität: Human ELISA, PLA Wirt: Maus Monoclonal 1B2 unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (Middle Region) antibodySUFUH Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio) WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Suppressor of Fused Homolog (SUFUH) antibodySUFUH Reaktivität: Human, Maus, Ratte WB, IHC, IF, IC Wirt: Kaninchen Polyclonal unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (N-Term) antibodySUFUH Reaktivität: Human WB, IHC, ELISA Wirt: Kaninchen Polyclonal unconjugated
-
- Applikationshinweise
-
WB 1:300-5000
IHC-P 1:200-400 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Konzentration
- 0.5 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Haltbarkeit
- 12 months
-
- Target
- SUFUH (Suppressor of Fused Homolog (SUFUH))
- Andere Bezeichnung
- SUFU (SUFUH Produkte)
- Hintergrund
-
Synonyms: SU FU, SU(F)U, Su(fu), SUFU_HUMAN, SUFUH, SUFUXL, Suppressor of fused homolog (Drosophila), Suppressor of fused homolog, OTTHUMP00000020374, OTTHUMP00000020377, OTTHUMP00000020379, PRO1280.
Background: Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).
- Gen-ID
- 51684
- UniProt
- Q9UMX1
- Pathways
- Hedgehog Signalweg, Tube Formation, Maintenance of Protein Location
-
