PKD2 Antikörper (AA 41-140) (HRP)

Produktnummer ABIN7091535

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PKD2 in ELISA und WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für PKD2 Antikörper (AA 41-140) (HRP) (ABIN7091535)

Target: PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PKD2 Antikörper ist konjugiert mit HRP

Applikation: ELISA, Western Blotting (WB)

Produktdetails anti-PKD2 Antikörper (HRP)

Bindungsspezifität: AA 41-140

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Cow,Pig,Horse,Rabbit,Zebrafish

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Polycystin 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Details zu PKD2

Target: PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))

Andere Bezeichnung: Polycystin 2

Hintergrund:

Synonyms: polycystic kidney disease 2, TRPP2, APKD2, C030034P18RIK, MGC138466, MGC138468, PC2, PKD2 (includes EG:5311), PKD4, POLYCISTIN-2, POLYCYSTIN 2, RGD1559992, TRPP2, Polycystic kidney disease 2 protein homolog, PC2.

Background: Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Functions as a calcium permeable cation channel.

Gen-ID: 5311

UniProt: Q13563

Pathways: cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity