PKD2 Antikörper (AA 41-140) (Biotin)
Kurzübersicht für PKD2 Antikörper (AA 41-140) (Biotin) (ABIN7091533)
Target
Alle PKD2 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 41-140
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Kreuzreaktivität
- Human
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Homologie
- Mouse,Rat,Cow,Pig,Horse,Rabbit,Zebrafish
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Aufreinigung
- Purified by Protein A.
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Immunogen
- KLH conjugated synthetic peptide derived from human Polycystin 2
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Isotyp
- IgG
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Applikationshinweise
- WB 1:300-5000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1 μg/μL
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Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C for 12 months.
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Haltbarkeit
- 12 months
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- PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))
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Andere Bezeichnung
- Polycystin 2
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Hintergrund
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Synonyms: polycystic kidney disease 2, TRPP2, APKD2, C030034P18RIK, MGC138466, MGC138468, PC2, PKD2 (includes EG:5311), PKD4, POLYCISTIN-2, POLYCYSTIN 2, RGD1559992, TRPP2, Polycystic kidney disease 2 protein homolog, PC2.
Background: Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Functions as a calcium permeable cation channel.
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Gen-ID
- 5311
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UniProt
- Q13563
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Pathways
- cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity
Target
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