MBD2 Antikörper (AA 10-228)

Produktnummer ABIN7091410

Der Maus Monoklonal Anti-MBD2-Antikörper wurde für WB und IHC (p) validiert. Er ist geeignet, MBD2 in Proben von Human zu detektieren.

Kurzübersicht für MBD2 Antikörper (AA 10-228) (ABIN7091410)

Target: MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MBD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: G7R2

Produktdetails anti-MBD2 Antikörper

Bindungsspezifität: AA 10-228

Homologie: Human

Immunogen: Recombinant human MBD2 between 10-228 amino acids.

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu MBD2

Target: MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))

Andere Bezeichnung: MBD2

Hintergrund:

Synonyms: Demethylase, DMTase, MBD 2, MBD2_HUMAN, MBD2a, Methyl CpG binding domain protein 2, Methyl CpG binding protein MBD2, Methyl-CpG-binding domain protein 2, Methyl-CpG-binding protein MBD2, NY CO 41.

Background: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.

Gen-ID: 8932

UniProt: Q9UBB5

Pathways: Chromatin Binding