Lamin A/C Antikörper (AA 1-100)

Produktnummer ABIN7091321

Dieses Anti-Lamin A/C-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Lamin A/C in WB. Geeignet für Human und Ratte.

Kurzübersicht für Lamin A/C Antikörper (AA 1-100) (ABIN7091321)

Target: Lamin A/C (LMNA)

Reaktivität: Human, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Lamin A/C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 3E1

Produktdetails anti-Lamin A/C Antikörper

Bindungsspezifität: AA 1-100

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,Dog,Cow,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: Recombinant human lamin A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu Lamin A/C

Target: Lamin A/C (LMNA)

Andere Bezeichnung: Lamin A/C

Hintergrund:

Synonyms: Lamin A + Lamin C, Lamin A + C, LMN1, 70 kDa lamin, CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, HGPS, IDC, LAMIN A, lamin A/C, LAMIN C, LDP1, LFP, LGMD1B, LMN 1, LMN A, LMN C, LMNA, LMNC, NY REN 32 antigen, PRO1, LMNA_HUMAN, Prelamin-A/C, Renal carcinoma antigen NY-REN-32.

Background: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]

Gen-ID: 4000

UniProt: P02545

Pathways: Apoptose, Caspase Kaskade in der Apoptose, ER-Nucleus Signaling, Protein targeting to Nucleus