TSC1 Antikörper (AA 131-230)
Kurzübersicht für TSC1 Antikörper (AA 131-230) (ABIN704846)
Target
Alle TSC1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 131-230
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Kreuzreaktivität
- Schaf
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Homologie
- Human,Mouse,Rat,Dog,Cow,Pig,Horse
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Aufreinigung
- Purified by Protein A.
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Immunogen
- KLH conjugated synthetic peptide derived from human Hamartin
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Isotyp
- IgG
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Applikationshinweise
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WB 1:300-5000
ELISA 1:500-1000 -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 μg/μL
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Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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Haltbarkeit
- 12 months
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: "DNA methylation Landscape of body size variation in sheep." in: Scientific reports, Vol. 5, pp. 13950, (2016) (PubMed).
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: "DNA methylation Landscape of body size variation in sheep." in: Scientific reports, Vol. 5, pp. 13950, (2016) (PubMed).
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- TSC1 (Tuberous Sclerosis 1 (TSC1))
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Andere Bezeichnung
- Hamartin/TSC1
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Hintergrund
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Synonyms: LAM, TSC1, Tuberous sclerosis 1 protein, TSC1_HUMAN.
Background: Hamartin, or TSC1, is a suspected tumor suppressor implicated in the disease tuberous sclerosis 1. It is a negative regulator of cell division controlling the transition from G0/G1 to S phase, and it seems to act through the phosphatidylinositol 3 kinase/Akt pathway. TSC1 interacts with tuberin m(TSC2), which is thought to be a GAP (GTPase Activating Protein) for the Rap1 and Rab5 small G Proteins. The Hamartin/Tuberin complex has been shown to inhibit mTor. Hamartin has also been shown to interact with ERM (Ezrin-Radixin-Moesin) proteins and with F-actin, suggesting a role for TSC proteins in modulation of cell adhesion and morphology.
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Gen-ID
- 7248
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UniProt
- Q92574
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Pathways
- RTK Signalweg, AMPK Signaling, Regulation of Cell Size, Tube Formation
Target
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