CD276 Antikörper (Biotin)

Produktnummer ABIN7077083

Dieser Maus Monoklonal Antikörper erkennt spezifisch CD276 in FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CD276 Antikörper (Biotin) (ABIN7077083)

Target: CD276

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD276 Antikörper ist konjugiert mit Biotin

Applikation: Flow Cytometry (FACS)

Güteklasse: GMP Grade

Klon: DCN-70

Produktdetails anti-CD276 Antikörper (Biotin)

Verwendungszweck: CD276 Biotin Antibody

Produktmerkmale: The clone DCN.70, a mouse monoclonal antibody selectively binds with a k type I membrane protein commonly known as CD276, a member of B7-H3 immunoregulatory family. It is not expressed by lymphocytes or granulocytes but weakly expressed on resting monocytes. Increased expression is observed on monocytes derived dendritic cells as well as in a variety of cancer types, including breast, pancreatic, and ovarian cancer. CD276 expression has been correlated with poor survival in ovarian cancer subjects. CD276 blockade, especially when combined with an anti-PD-1 blockade, is a promising strategy for the treatment of B7-H3-expressing NSCLCs that arerefractory to anti-PD-1 therapy, making CD276 a promising clinical molecular target.

Aufreinigung: Purified

Reinheit: >95 %

Immunogen: Human Dendritic Cells

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS pH 7.2, 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C, Conjugated antibodies should never be frozen.

Details zu CD276

Target: CD276

Andere Bezeichnung: CD276

Gen-ID: 80381

UniProt: Q5ZPR3

Pathways: Cancer Immune Checkpoints