ZNF746 Antikörper
Kurzübersicht für ZNF746 Antikörper (ABIN7076272)
Target
Alle ZNF746 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
-
-
Kreuzreaktivität
- Human, Ratte
-
Aufreinigung
- Affinity purification
-
Immunogen
- Recombinant protein corresponding to Mouse PARIS
-
-
-
-
Applikationshinweise
- WB (H) 1:500-1:1000, IHC/IF (M,R) 1:1500-1:3000/1:1500-1:3000
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Liquid
-
Buffer
- PBS, pH 7.4, 0.02 % sodium azide
-
Konservierungsmittel
- Sodium azide
-
Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Lagerung
- -20 °C
-
-
- ZNF746 (Zinc Finger Protein 746 (ZNF746))
-
Andere Bezeichnung
- PARIS
-
Hintergrund
- ZNF746, also named as PARIS, which belongs to the krueppel C2H2-type zinc-finger protein family. ZNF746 mainly localizes to the cytoplasm and probably translocates to the nucleus to repress selected genes. ZNF746 as a transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. ZNF746 may act as a downstream effector of PRKN and contribute to neurodegeneration in Parkinson disease cases caused by defects in PRKN.
-
Molekulargewicht
- 100 kDa
-
Gen-ID
- 69228
-
NCBI Accession
- NP_001156947
-
UniProt
- Q3U133
Target
-