MPL Antikörper
Kurzübersicht für MPL Antikörper (ABIN7074718)
Target
Alle MPL Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
-
-
Kreuzreaktivität
- Ratte
-
Aufreinigung
- Affinity purification
-
Immunogen
- KLH conjugated Synthetic peptide corresponding to Mouse TPOR
-
-
-
-
Applikationshinweise
- IHC/IF (M,R) 1:500-1:2000
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Liquid
-
Buffer
- PBS, pH 7.4, 0.02 % sodium azide
-
Konservierungsmittel
- Sodium azide
-
Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Lagerung
- -20 °C
-
-
- MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))
-
Andere Bezeichnung
- TPOR/MPL
-
Hintergrund
- The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.
-
Gen-ID
- 17480
-
NCBI Accession
- NP_001116421
-
UniProt
- Q08351
-
Pathways
- JAK-STAT Signalweg
Target
-