B-Cell Linker Antikörper
Kurzübersicht für B-Cell Linker Antikörper (ABIN7073174)
Target
Alle B-Cell Linker (BLNK) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Kreuzreaktivität
- Ratte
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Aufreinigung
- Affinity purification
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Immunogen
- Recombinant protein corresponding to Mouse BLNK
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Applikationshinweise
- IHC/IF (M,R) 1:2500-1:5000/1:1500-1:2500
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS, pH 7.4, 0.02 % sodium azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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- B-Cell Linker (BLNK)
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Andere Bezeichnung
- BLNK
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Hintergrund
- The function of BLNK was first illustrated in BLNK deficient DT40 cells, a chicken B-cell line, which exhibited an abrogated intracellular calcium mobilisation response and impaired activation of MAP kinases p38, JNK, and to a lesser degree ERK upon B-cell receptor (BCR) activation as compared to wild type DT40 cells. In knockout mice, BLNK deficiency results in a partial block in B-cell development, and in humans BLNK deficiency results in a much more profound block in B-cell development. Linker or adaptor proteins provide mechanisms by which receptors can amplify and regulate downstream effector proteins. The B-cell linker protein is essential for normal B-cell development.
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Gen-ID
- 17060
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NCBI Accession
- NP_032554
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UniProt
- Q9QUN3
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Pathways
- BCR Signaling
Target
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