WTX Antikörper

Produktnummer ABIN7073078

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch WTX in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für WTX Antikörper (ABIN7073078)

Target: WTX (AMER1) (APC Membrane Recruitment Protein 1 (AMER1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WTX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-WTX Antikörper

Kreuzreaktivität: Human, Ratte

Aufreinigung: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse FAM123B

Anwendungsinformationen

Applikationshinweise: WB (H,M,R) 1: 500-1: 1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu WTX

Target: WTX (AMER1) (APC Membrane Recruitment Protein 1 (AMER1))

Andere Bezeichnung: FAM123B

Hintergrund: Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development.

Molekulargewicht: 125 kDa

Gen-ID: 72345

NCBI Accession: NP_780388

UniProt: Q7TS75