Rekombinanter CD80 Antikörper

Produktnummer ABIN7072690

Dieses Kaninchen Chimeric-Antikörper erkennt spezifisch CD80 in ELISA und BR. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Rekombinanter CD80 Antikörper (ABIN7072690)

Target: CD80

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser CD80 Antikörper ist unkonjugiert

Applikation: ELISA, Blocking Reagent (BR)

Klon: 16C10

Produktdetails anti-CD80 Antikörper

Verwendungszweck: Anti-CD80 [16C10], Rabbit IgG, lambda

Spezifität: This antibody binds human CD80 and inhibits the B7.1:CD28 pathway.

Produktmerkmale:

Original Species of Ab: Rhesus Macaque

Original Format of Ab: IgG1

Aufreinigung: Protein A affinity purified

Immunogen: This antibody was generated by immunization of cynomolgus monkeys with human B7.1 antigen.

Isotyp: IgG lambda

Anwendungsinformationen

Applikationshinweise: This antibody can be used for identification of human B7.1 antigen and is capable of inhibiting the binding of B7.1 to CD28, however it does not block the binding of B7.1 to CTLA-4. This antibody further inhibits the production of IL-2. Blocking of the primary activation signal between CD28 and B7.1 (CD80) with these antibodies while allowing the unimpaired or coincident interaction of CTLA-4 and B7.1 represents a combined antagonistic effect on positive co-stimulation with an agonistic effect on negative signaling. The binding of the antibody to soluble B7.1 was tested using ELISA. This antibody tested positive for binding to human C1q protein. This antibody is reported to cause keratinocyte hyperproliferation and decrease in psoriasis by inhibiting the B7:CD28 pathway. This antibody is further reported to be useful for the treatment of intestinal inflammation and rheumatoid arthritis.

Kommentare:

This chimeric rabbit antibody was made using the variable domain sequences of the original IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu CD80

Target: CD80

Andere Bezeichnung: CD80

Hintergrund: B7.1, CD28L, CD28LG, B7-1, B7, BB1, B7/BB1,T-lymphocyte activation antigen CD80, Activation B7-1 antigen, CTLA-4 counter-receptor B7.1, CTLA4L, CTLA-4L

UniProt: P33681

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints