Rekombinanter CD59 Antikörper

Produktnummer ABIN7072634

Der Kaninchen Chimeric anti-CD59 Antikörper wird verwendet zum Nachweis von CD59 in Proben von Human. Er wurde validiert für IHC, FACS und IF.

Kurzübersicht für Rekombinanter CD59 Antikörper (ABIN7072634)

Target: CD59

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser CD59 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Klon: 193-27

Produktdetails anti-CD59 Antikörper

Verwendungszweck: Anti-CD59 [193-27], Rabbit IgG, kappa

Spezifität:

This antibody recognizes human CD59 which is a glycosyl phosphatidyl-inositol (GPI)-anchored cell surface protein. It regulates complement-mediated cell lysis, and is involved in lymphocyte signal transduction.

Application Notes original Clone: The antibody 193-27 is recommended for the identification and analysis of CD59 via various experimental techniques (Bellosillo et al., 2001). Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH) and thus this antibody is useful for study on GPI-anchored proteins, PNH and CD59 functions.

Produktmerkmale: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgM format, for improved compatibility with existing reagents, assays and techniques.

Aufreinigung: Protein A affinity purified

Immunogen: This antibody was raised by immunizng mice with stimulated human leukocytes.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

OriginalSpeciesName: Mouse

OriginalFormat: IgM

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu CD59

Target: CD59

Andere Bezeichnung: CD59

Hintergrund: 1F5, 1F5 antigen, CD59 glycoprotein, 20 kDa homologous restriction factor, HRF-20, HRF20, MAC-inhibitory protein, MAC-IP, MEM43 antigen, Membrane attack complex inhibition factor, MACIF, Membrane inhibitor of reactive lysis, MIRL, Protectin

UniProt: P13987

Pathways: Komplementsystem