Rekombinanter TNFSF15 Antikörper

Produktnummer ABIN7072491

Dieses Anti-TNFSF15-Antikörper ist ein Kaninchen Chimeric-Antikörper zur Detektion von TNFSF15 in IF, FACS und BP. Geeignet für Maus.

Kurzübersicht für Rekombinanter TNFSF15 Antikörper (ABIN7072491)

Target: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Antikörpertyp: Recombinant Antibody

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser TNFSF15 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Flow Cytometry (FACS), Blocking Peptide (BP)

Klon: TAN2-2

Produktdetails anti-TNFSF15 Antikörper

Verwendungszweck: Anti-TL1A [TAN2-2], Rabbit IgG, kappa

Spezifität: This antibody is specific for TL1A, a member of the TNF ligand family. TL1A is expressed by endothelial cells, tissue macrophages, monocyte-derived dendritic cells, plasma cells and lamina propria-derived lymphocytes. Among peripheral blood cells, TL1A has been shown to be expressed predominantly by CD4+CCR9+ lymphocytes. Its expression has been shown to be induced by TNF alpha, IL-1 alpha and IFN gamma.

Produktmerkmale:

Original Species of Ab: Rat

Original Format of Ab: IgG2a

Aufreinigung: Protein A affinity purified

Immunogen: This antibody was raised by immunising rats with a soluble recombinant TL1A (T77-L252):Fc protein.

Isotyp: IgG kappa

Anwendungsinformationen

Applikationshinweise: This antibody has been used in FACS analyses to reveal the role of TL1A in humoral immune responses and its mechanism of action in the development of collagen-induced arthritis (Wang et al, 2013), and in immunofluorescence confocal microscopy to demonstrate how chronic DR3 signaling could promote pathogenesis in inflammatory bowel disease (Taraban et al, 2011). The therapeutic potential of this antagonistic anti-TL1A antibody in countering the DR3-TL1A pathway in the inflammatory joint disease has been confirmed in both of the murine adjuvant-induced arthritis (AIA) and collagen-induced arthritis (CIA) models (Bull et al, 2008). In addition, this antibody has been demonstrated to prevent chronic colitis and attenuate established colitis by down-regulation of both T-helper 1 and T-helper 17 activation (Takedatsu et al, 2008).

Kommentare:

This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG format, for improved compatibility with existing reagents, assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu TNFSF15

Target: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Andere Bezeichnung: TL1A

Hintergrund: Tnfsf15, bM20K13.3 (tumor necrosis factor (ligand) superfamily, member 15), MGC129934, MGC129935, TL1, TNF ligand-related molecule 1, TNF superfamily ligand TL1A, tumor necrosis factor (ligand) superfamily member 15, tumor necrosis factor (ligand) superfamily, member 15, tumor necrosis factor ligand 1B, Tumor necrosis factor ligand superfamily member 15, Vascular endothelial cell growth inhibitor, vascular endothelial growth inhibitor, vascular endothelial growth inhibitor-192A, VEGI, VEGI192A

UniProt: Q5UBV8

Pathways: Positive Regulation of Endopeptidase Activity, Autophagie