Rekombinanter CD80 (Galiximab Biosimilar) Antikörper

Produktnummer ABIN7072388

Der Kaninchen Chimeric Anti-CD80 (Galiximab Biosimilar)-Antikörper wurde für BR, ELISA, FACS, IHC, IP und WB validiert. Er ist geeignet, CD80 (Galiximab Biosimilar) in Proben von Human zu detektieren.

Kurzübersicht für Rekombinanter CD80 (Galiximab Biosimilar) Antikörper (ABIN7072388)

Target: CD80 (Galiximab Biosimilar)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser CD80 (Galiximab Biosimilar) Antikörper ist unkonjugiert

Applikation: Blocking Reagent (BR), ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)

Klon: IDEC-114

Produktdetails anti-CD80 (Galiximab Biosimilar) Antikörper

Verwendungszweck: Anti-CD80 [IDEC-114 (Galiximab)], Rabbit IgG, lambda

Spezifität: Galiximab is a primatized mAb which consists of human constant and primate (cynomolgus macaque) variable regions and binds specifically to CD80. CD80 is a surface glycoprotein and a member of the B7 family of costimulatory molecules. CD80 antigen regulates T cell activation (through interacting with CD28 or CD152) and is expressed transiently in antigen-presenting cells, T cells and normal B cells, and expressed consitutively on various subtypes of B-cell lymphomas.

Produktmerkmale:

Original Species of Ab: Human

Original Format of Ab: IgG1

Aufreinigung: Protein A affinity purified

Immunogen: Galiximab was prepared by immunizing cynomolgus monkeys with recombinant CD80 antigen. The variable regions of the light and heavy chains were then cloned by being incorporated into a cassette vector (N5LG1) containing human constant region genes and subsequently transfected into the Dg44 CHO cell line (Hariharan K, 2013)

Isotyp: IgG lambda

Anwendungsinformationen

Applikationshinweise: Galiximab acts to decrease in cell proliferation, inhibition of the constitutively active NF-κB pathway, increase in apoptosis and ADCC against various B-cell lymphoma cell lines. Galiximb affects CD28 and CD152 interactions with CD80. This antibody can also be used for FC, WB, ELISA, IP and IHC.

Kommentare:

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu CD80 (Galiximab Biosimilar)

Target: CD80 (Galiximab Biosimilar)

Substanzklasse: Biosimilar

Hintergrund: B7-1, T-lymphocyte activation antigen CD80, Activation B7-1 antigen, BB1, CTLA-4 counter-receptor B7.1, B7

UniProt: P33681