Rekombinanter CD80 (Galiximab Biosimilar) Antikörper
Kurzübersicht für Rekombinanter CD80 (Galiximab Biosimilar) Antikörper (ABIN7795110)
Target
Antikörpertyp
Reaktivität
Wirt
Klonalität
Konjugat
Applikation
Güteklasse
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Expressionssystem
- Mammalian cells
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Verwendungszweck
- Galiximab Biosimilar, CD80 Monoclonal Antibody
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Produktmerkmale
- A humanized IgG1 monoclonal antibody directed against CD80, the natural ligand for the T-cell antigen CD28 which mediates T-cell and B-cell adhesion. Galiximab binds to CD80 expressed on the cell surfaces of follicular lymphomas, resulting in antibody-dependent cell-mediated cytotoxicity (ADCC). CD80 is expressed on activated B-cells and gamma-interferon-stimulated monocytes and is often expressed at low levels on the surfaces of follicular lymphoma cells and other lymphoid malignancies. Galiximab, an IgG(1) anti-CD80 antibody, binds to CD80, a costimulatory molecule involved in T-cell activation. Reduction in lesional, activated T cells induces improvement in psoriatic plaques.
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Aufreinigung
- Protein A or G affinity column
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Reinheit
- >95 % by reducing SDS-PAGE
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Endotoxin-Niveau
- < 1 EU per 1 mg of the protein by the LAL method
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Immunogen
- Human CD80
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- > 3 mg/mL
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- Short time 2 to 8°C as supplied. Long time -20°C to -70°C as supplied.
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- CD80 (Galiximab Biosimilar)
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Andere Bezeichnung
- Galiximab Biosimilar
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Substanzklasse
- Biosimilar
Target
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