VIPR1 Antikörper (Extracellular, N-Term)

Produktnummer ABIN7887184

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch VIPR1 in WB, IHC, IF, FACS, LCI und IC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für VIPR1 Antikörper (Extracellular, N-Term) (ABIN7887184)

Target: VIPR1 (Vasoactive Intestinal Peptide Receptor 1 (VIPR1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VIPR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Live Cell Imaging (LCI), Immunochromatography (IC)

Produktdetails anti-VIPR1 Antikörper

Bindungsspezifität: AA 52-65, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to VPAC1 Receptor

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Human - 13,14 amino acid residues identical, rat,mouse - 12

Produktmerkmale: Anti-VPAC1 (VIPR1) (extracellular) Antibody (ABIN7043875, ABIN7045329 and ABIN7045330) is a highly specific antibody directed against an epitope of human VIP and PACAP receptor 1. The antibody can be used in western blot, immunohistochemistry, immunocytochemistry, live cell imaging, and indirect flow cytometry applications. It has been designed to recognize VPAC1 from mouse, rat, and human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)EEAQLENETIG(S)SK, corresponding to amino acid residues 52-65 of human VPAC1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:400

FC: 2.5 mg per reaction

ICC: 1:25

IHC: 1:100

IP: The optimal concentration should be determined by the user

Kommentare:

Cited Application: IFC

Negative Control: (ABIN7237555)

Blocking Peptide: (ABIN7237555)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu VIPR1

Target: VIPR1 (Vasoactive Intestinal Peptide Receptor 1 (VIPR1))

Andere Bezeichnung: VIPR1

Hintergrund:

Synonyms: VIP and PACAP receptor 1, Vasoactive intestinal polypeptide receptor 1, Pituitary adenylate cyclase-activating polypeptide type II receptor, PACAP type II receptor, PACAP-R2

Description: Vasointestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) belong to the glucagon hormone superfamily, which includes secretin, growth hormone-releasing hormone (GHRH), glucagon, glucagon-like peptides 1 and 2 (GLP-1 and GLP-2), peptide histidine methionine (PHM), and glucose-dependent insulinotropic polypeptide (GIP)1. PACAP and VIP effects have been described in the digestive tract, cardiovascular system, airways, reproductive system, immune system, endocrine glands, and brain2. VIP and PACAP share a common G-protein coupled receptor, VPAC13.VPAC1 is a membrane-associated protein and shares significant homology with members of the G-protein coupled class B receptor family, the most important of which is the presence of large N-terminal extracellular domains which contain 10 highly conserved amino acids including six cysteines, putative N-terminal leader sequences and several potential N-glycosylation sites4. In the CNS, VPAC1 receptors are abundantly localized in piriform cortex, cerebral cortex, suprachiasmatic nucleus, hippocampus, and pineal gland5. In peripheral tissues, VPAC1 receptors have been found in breast, kidney, liver, lung, prostate, spleen, and mucosa of the gastrointestinal tract6. VPAC1 mediates a large array of VIP and PACAP actions on exocrine secretion, hormones release, muscle relaxation, metabolism, fetus growth, tumor cells and embryonic brain development7.

Gen-ID: 7433

NCBI Accession: NM_004624

UniProt: P32241