TBXA2R Antikörper (AA 225-239)

Produktnummer ABIN7043809

Produktdetails anti-TBXA2R Antikörper

Target: TBXA2R (Thromboxane A2 Receptor (TBXA2R))

Bindungsspezifität: AA 225-239

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TBXA2R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Verwendungszweck: A Rabbit Polyclonal Antibody to Thromboxane A2 Receptor

Spezifität: 3rd intracellular loop

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Rat - 14,15 amino acid residues identical, human - 12, mouse - 13

Produktmerkmale: Anti-Thromboxane A2 Receptor Antibody (ABIN7043809, ABIN7045124 and ABIN7045125)) is a highly specific antibody directed against an epitope of the rat TBXA2R. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize TBXA2R from rat, mouse, and human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)HAREATQRPRD(S)EVE, corresponding to amino acid residues 225-239 of rat TBXA2R

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200

Application Dilutions Western blot wb: 1:200

Kommentare:

Negative Control: BLP-PR069

Blocking Peptide: BLP-PR069

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW).

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Details zu TBXA2R

Target: TBXA2R (Thromboxane A2 Receptor (TBXA2R))

Andere Bezeichnung: TBXA2R (TBXA2R Produkte)

Hintergrund: Prostanoid TP receptor, TXA2-R, TBXA2R,Thromboxane A2 (TxA2) is a prostanoid that is synthesized from arachidonic acid and plays an important role in haemostasis, a process regulating platelet aggregation and vascular tone. Thromboxane A2 binds to the thromboxane A2 receptor (TBXA2R) to induce strong vasoconstriction in renal arteries.Thromboxane A2 receptor is a seven-transmembrane G-protein coupled receptor localized on the cell membrane and in intracellular compartments. TBXA2R is expressed in the central nervous system in several types of cells, such as microglia, oligodendrocytes and astrocytes. Imbalances in the levels of the receptor is widely implicated in several cardiovascular, pulmonary, renal and prostate pathologies1-3.Thromboxane A2 receptor mediates vasoconstriction and ischemia and its activation is implicated in atherosclerosis and inflammation. Activation of the receptor induces endothelial cell apoptosis by inhibiting Akt phosphorylation and also inhibits endothelial cell migration and angiogenesis by decreasing Akt and eNOS phosphorylation1-3.

Alternative names: Thromboxane A2 Receptor, Prostanoid TP receptor, TXA2-R, TBXA2R

Gen-ID: 24816

NCBI Accession: NM_001060

UniProt: P34978