STOML2 Antikörper (Intracellular)

Produktnummer ABIN7886510

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch STOML2 in WB. Es zeigt Reaktivität gegenüber Proben von Ratte.

Kurzübersicht für STOML2 Antikörper (Intracellular) (ABIN7886510)

Target: STOML2 (Stomatin (EPB72)-Like 2 (STOML2))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STOML2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-STOML2 Antikörper

Bindungsspezifität: AA 208-222, Intracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to Stomatin-like Protein 2

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Mouse,human - identical

Produktmerkmale: Anti-STOML2/ Antibody (ABIN7043779, ABIN7044518 and ABIN7044519) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot analysis. It has been designed to recognize Stomatin-like protein 2 from human, rat, and mouse samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)EGTRESAINVAEGKK, corresponding to amino acid residues 208-222 of rat Stomatin-like protein 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:400-1:800

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7237288)

Blocking Peptide: (ABIN7237288)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu STOML2

Target: STOML2 (Stomatin (EPB72)-Like 2 (STOML2))

Andere Bezeichnung: STOML2

Hintergrund:

Synonyms: Paraprotein target 7, EPB72-like protein 2, Stomatin-like protein 2

Description: Stomatin-like protein 2 (STOML2, SLP-2) is a key protein on the mitochondrial inner membrane and a member of the stomatin superfamily. STOML2 is widely expressed in human tissues such as the brain, lung, and kidneys and interacts with prohibitin-1 and 2. It plays an important role in numerous physiological processes including organizing sphingolipid and cholesterol-rich lipid rafts, regulating ion channel conductance, and linking other integral membrane proteins to the peripheral cytoskeleton1,2.STOML2 shares a consensus stomatin signature sequence that defines the stomatin gene family. However, it lacks a NH2-terminal hydrophobic domain shared by other members3.Studies show that STOML2 expression is upregulated in various human cancer tissues including gastric cancer, endometrial adenocarcinoma, and breast cancer. The protein may play an important role in the incidence and development of tumor and it is suggested that SLP-2 is a potential oncogene. Knockdown of STOML2 protein significantly restrains the viability, migration, and invasion of hepatoma cell line1,2.

Gen-ID: 298203

NCBI Accession: NM_013442

UniProt: Q4FZT0

Pathways: SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion