STOML2 Antikörper (Intracellular)

Produktnummer ABIN7043779

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch STOML2 in WB. Er zeigt eine Reaktivität gegenüber Ratte.

Kurzübersicht für STOML2 Antikörper (Intracellular) (ABIN7043779)

Target: STOML2 (Stomatin (EPB72)-Like 2 (STOML2))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STOML2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-STOML2 Antikörper

Bindungsspezifität: AA 208-222, Intracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to Stomatin-like Protein 2

Spezifität: Intracellular

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Mouse,human - identical

Produktmerkmale: Anti-STOML2/ Antibody (ABIN7043779, ABIN7044518 and ABIN7044519) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot analysis. It has been designed to recognize Stomatin-like protein 2 from human, rat, and mouse samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)EGTRESAINVAEGKK, corresponding to amino acid residues 208-222 of rat Stomatin-like protein 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

Application Dilutions Western blot wb: 1:400-1:800

Kommentare:

Negative Control: (ABIN7237288)

Blocking Peptide: (ABIN7237288)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Details zu STOML2

Target: STOML2 (Stomatin (EPB72)-Like 2 (STOML2))

Andere Bezeichnung: STOML2

Hintergrund: Paraprotein target 7, EPB72-like protein 2, Stomatin-like protein 2,Stomatin-like protein 2 (STOML2, SLP-2) is a key protein on the mitochondrial inner membrane and a member of the stomatin superfamily. STOML2 is widely expressed in human tissues such as the brain, lung, and kidneys and interacts with prohibitin-1 and 2. It plays an important role in numerous physiological processes including organizing sphingolipid and cholesterol-rich lipid rafts, regulating ion channel conductance, and linking other integral membrane proteins to the peripheral cytoskeleton1,2.STOML2 shares a consensus stomatin signature sequence that defines the stomatin gene family. However, it lacks a NH2-terminal hydrophobic domain shared by other members3.Studies show that STOML2 expression is upregulated in various human cancer tissues including gastric cancer, endometrial adenocarcinoma, and breast cancer. The protein may play an important role in the incidence and development of tumor and it is suggested that SLP-2 is a potential oncogene. Knockdown of STOML2 protein significantly restrains the viability, migration, and invasion of hepatoma cell line1,2.

Alternative names: STOML2/SLP-2, Paraprotein target 7, EPB72-like protein 2, Stomatin-like protein 2

Gen-ID: 298203

NCBI Accession: NM_013442

UniProt: Q4FZT0

Pathways: SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion