SLC29A3 Antikörper (Intracellular, N-Term)

Produktnummer ABIN7886763

Der Kaninchen Polyklonal anti-SLC29A3 Antikörper (ABIN7886763) detektiert spezifisch SLC29A3 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Ratte.

Kurzübersicht für SLC29A3 Antikörper (Intracellular, N-Term) (ABIN7886763)

Target: SLC29A3 (Solute Carrier Family 29 Member 3 (SLC29A3))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLC29A3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SLC29A3 Antikörper

Bindungsspezifität: AA 37-49, Intracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to Equilibrative Nucleoside Transporter 3 (SLC29A3)

Kreuzreaktivität: Maus, Ratte

Homologie: Mouse - identical, human - 10,13 amino acid residues identical

Produktmerkmale: Anti-ENT3 (SLC29A3) Antibody (ABIN7043712, ABIN7044802 and ABIN7044803) is a highly specific antibody directed against an epitope of the rat equilibrative nucleoside transporter 3. The antibody can be used in western blot analysis. It has been designed to recognize ENT3 from rat, mouse, and human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)DYPAPGLQRPEDR, corresponding to amino acid residues 37-49 of rat ENT3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7237052)

Blocking Peptide: (ABIN7237052)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu SLC29A3

Target: SLC29A3 (Solute Carrier Family 29 Member 3 (SLC29A3))

Andere Bezeichnung: SLC29A3

Hintergrund:

Synonyms: Equilibrative nucleoside transporter 3

Description: Equilibrative nucleoside transporter 3 (ENT3) is responsible for transporting nucleotide synthesis precursors, such as hydrophilic nucleosides and nucleobases within cells1. ENT3 structure includes 11 transmembrane domains and a 51-residue hydrophilic N-terminal region containing two dileucine motifs that are characteristic of endosomal/lysosomal targeting sequences1,2.ENT3 is encoded by the SLC29A3 gene and is expressed in several mouse and human tissues such as placenta, heart, neurons, and astrocytes. In addition, human ENT3 is predominantly expressed in mitochondria in human hepatocytes. Human ENTs are high-capacity transporters, bidirectional, Na+-independent with a wide substrate selectivity1,2. The human ENT family consists of four members: ENT1- ENT4. Nucleoside transport function of ENT3 is maximal at pH 5.5 suggesting that the protein is localized to acidic intracellular compartments, probably lysosomes1,2.Studies show that mutations in human ENT3 can cause various clinical disorders including H syndrome, pigmented hypertrichosis with insulin-dependent diabetes mellitus syndrome, lysosomal storage-like disorders and mitochondrial disorders1,2.

Gen-ID: 353307

NCBI Accession: NM_018344

UniProt: Q80WK7