Serotonin Receptor 1A Antikörper (3rd Intracellular Loop)

Produktnummer ABIN7887146

Der Kaninchen Polyklonal anti-Serotonin Receptor 1A Antikörper wird verwendet zum Nachweis von Serotonin Receptor 1A in Proben von Ratte. Er wurde validiert für WB, IHC und IF.

Kurzübersicht für Serotonin Receptor 1A Antikörper (3rd Intracellular Loop) (ABIN7887146)

Target: Serotonin Receptor 1A (HTR1A)

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Serotonin Receptor 1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-Serotonin Receptor 1A Antikörper

Bindungsspezifität: 3rd Intracellular Loop, AA 251-266

Verwendungszweck: A Rabbit Polyclonal Antibody to 5-Hydroxytryptamine Receptor 1A

Kreuzreaktivität: Maus, Ratte

Kreuzreaktivität (Details): Will not recognize human 5-hydroxytryptamine receptor 1A.

Homologie: Mouse - identical

Produktmerkmale: Anti-5HT1A Receptor (HTR1A) Antibody is directed against an intracellular epitope of the rat 5-Hydroxytryptamine receptor 1A. Anti-5HT1A Receptor (HTR1A) Antibody (ABIN7043615, ABIN7045278 and ABIN7045279) can be used for western blot and immunohistochemistry applications. It has been designed to recognize 5HT1A receptor from rat and mouse samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: KKSLNGQPGSGDWRRC, corresponding to amino acid residues 251-266 of rat 5-Hydroxytryptamine receptor 1A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:100

IP: The optimal concentration should be determined by the user

Kommentare:

Cited Application: IP

Negative Control: (ABIN7236780)

Blocking Peptide: (ABIN7236780)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu Serotonin Receptor 1A

Target: Serotonin Receptor 1A (HTR1A)

Andere Bezeichnung: HTR1A

Hintergrund:

Synonyms: 5-Hydroxytryptamine receptor 1A, Serotonin receptor 1A

Description: Serotonin (5-hydroxytryptamine, 5-HT1) is an important neurotransmitter in the central nervous system (CNS) that exerts its neuronal activity via 5-HT receptors.5-HT receptors are subdivided into seven families termed 5-HT1 through 5-HT7.1 The 5-HT receptor families belong to the G-protein coupled receptor superfamily with the exception of 5-HT3 receptor class which belongs to the ligand-gated ion channels.2The 5-HT1 receptor class comprises of five different receptors (5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F) which share 41-63 % overall sequence identity and couple preferentially to Gi/Go to inhibit cAMP formation.2The 5-HT1A receptor is the most widespread of all the 5-HT receptors. In the CNS, 5-HT1A receptors exist in the cerebral cortex, hippocampus, septum, amygdala and raphe nucelus in high densities, and was also demonstrated in a variety of tissues from various species.2,3 Activation of 5-HT1A receptor decreases blood pressure and heart rate, and is involved in learning, memory, relieving anxiety and depression.1,4

Gen-ID: 24473

NCBI Accession: NM_000524

UniProt: P19327

Pathways: JAK-STAT Signalweg, Synaptic Membrane, Feeding Behaviour