Serotonin Receptor 1A Antikörper (AA 251-266)
Kurzübersicht für Serotonin Receptor 1A Antikörper (AA 251-266) (ABIN7043615)
Target
Alle Serotonin Receptor 1A (HTR1A) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 251-266
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Verwendungszweck
- A Rabbit Polyclonal Antibody to 5-Hydroxytryptamine Receptor 1A
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Spezifität
- 3rd intracellular loop
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Kreuzreaktivität
- Maus, Ratte
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Kreuzreaktivität (Details)
- Will not recognize human 5-hydroxytryptamine receptor 1A.
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Homologie
- Mouse - identical
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Produktmerkmale
- Anti-5HT1A Receptor (HTR1A) Antibody is directed against an intracellular epitope of the rat 5-Hydroxytryptamine receptor 1A. Anti-5HT1A Receptor (HTR1A) Antibody (ABIN7043615, ABIN7045278 and ABIN7045279) can be used for western blot and immunohistochemistry applications. It has been designed to recognize 5HT1A receptor from rat and mouse samples.
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Aufreinigung
- Affinity purified on immobilized antigen.
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Immunogen
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Immunogen: Synthetic peptide
Immunogen Sequence: KKSLNGQPGSGDWRRC, corresponding to amino acid residues 251-266 of rat 5-Hydroxytryptamine receptor 1A
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Isotyp
- IgG
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Applikationshinweise
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100
Application Dilutions Western blot wb: 1:200
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Kommentare
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Cited Application: IP
Negative Control: (ABIN7236780)
Blocking Peptide: (ABIN7236780)
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- 0.2 mL double distilled water (DDW).
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Konzentration
- 1 mg/mL
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Buffer
- PBS pH 7.4
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- Serotonin Receptor 1A (HTR1A)
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Andere Bezeichnung
- HTR1A
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Hintergrund
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5-Hydroxytryptamine receptor 1A, Serotonin receptor 1A,Serotonin (5-hydroxytryptamine, 5-HT1) is an important neurotransmitter in the central nervous system (CNS) that exerts its neuronal activity via 5-HT receptors.5-HT receptors are subdivided into seven families termed 5-HT1 through 5-HT7.1 The 5-HT receptor families belong to the G-protein coupled receptor superfamily with the exception of 5-HT3 receptor class which belongs to the ligand-gated ion channels.2The 5-HT1 receptor class comprises of five different receptors (5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F) which share 41-63 % overall sequence identity and couple preferentially to Gi/Go to inhibit cAMP formation.2The 5-HT1A receptor is the most widespread of all the 5-HT receptors. In the CNS, 5-HT1A receptors exist in the cerebral cortex, hippocampus, septum, amygdala and raphe nucelus in high densities, and was also demonstrated in a variety of tissues from various species.2,3 Activation of 5-HT1A receptor decreases blood pressure and heart rate, and is involved in learning, memory, relieving anxiety and depression.1,4
Alternative names: 5HT1A Receptor (HTR1A), 5-Hydroxytryptamine receptor 1A, Serotonin receptor 1A -
Gen-ID
- 24473
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NCBI Accession
- NM_000524
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UniProt
- P19327
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Pathways
- JAK-STAT Signalweg, Synaptic Membrane, Feeding Behaviour
Target
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