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Serotonin Receptor 1A Antikörper (AA 251-266)

Der Kaninchen Polyklonal Anti-Serotonin Receptor 1A-Antikörper wurde für WB, IHC und IF validiert. Er ist geeignet, Serotonin Receptor 1A in Proben von Ratte zu detektieren.
Produktnummer ABIN7043615

Kurzübersicht für Serotonin Receptor 1A Antikörper (AA 251-266) (ABIN7043615)

Target

Alle Serotonin Receptor 1A (HTR1A) Antikörper anzeigen
Serotonin Receptor 1A (HTR1A)

Reaktivität

  • 51
  • 31
  • 31
  • 2
  • 1
  • 1
Ratte

Wirt

  • 43
  • 6
  • 2
Kaninchen

Klonalität

  • 46
  • 5
Polyklonal

Konjugat

  • 25
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Serotonin Receptor 1A Antikörper ist unkonjugiert

Applikation

  • 35
  • 17
  • 14
  • 13
  • 13
  • 7
  • 5
  • 5
  • 4
  • 4
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
  • Bindungsspezifität

    • 15
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 251-266

    Verwendungszweck

    A Rabbit Polyclonal Antibody to 5-Hydroxytryptamine Receptor 1A

    Spezifität

    3rd intracellular loop

    Kreuzreaktivität

    Maus, Ratte

    Kreuzreaktivität (Details)

    Will not recognize human 5-hydroxytryptamine receptor 1A.

    Homologie

    Mouse - identical

    Produktmerkmale

    Anti-5HT1A Receptor (HTR1A) Antibody is directed against an intracellular epitope of the rat 5-Hydroxytryptamine receptor 1A. Anti-5HT1A Receptor (HTR1A) Antibody (ABIN7043615, ABIN7045278 and ABIN7045279) can be used for western blot and immunohistochemistry applications. It has been designed to recognize 5HT1A receptor from rat and mouse samples.

    Aufreinigung

    Affinity purified on immobilized antigen.

    Immunogen

    Immunogen: Synthetic peptide

    Immunogen Sequence: KKSLNGQPGSGDWRRC, corresponding to amino acid residues 251-266 of rat 5-Hydroxytryptamine receptor 1A

    Isotyp

    IgG
  • Applikationshinweise

    Antigen preadsorption control: 1 μg peptide per 1 μg antibody

    Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100

    Application Dilutions Western blot wb: 1:200

    Kommentare

    Cited Application: IP

    Negative Control: (ABIN7236780)

    Blocking Peptide: (ABIN7236780)

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    0.2 mL double distilled water (DDW).

    Konzentration

    1 mg/mL

    Buffer

    PBS pH 7.4

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

    Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

  • Target

    Serotonin Receptor 1A (HTR1A)

    Andere Bezeichnung

    HTR1A

    Hintergrund

    5-Hydroxytryptamine receptor 1A, Serotonin receptor 1A,Serotonin (5-hydroxytryptamine, 5-HT1) is an important neurotransmitter in the central nervous system (CNS) that exerts its neuronal activity via 5-HT receptors.5-HT receptors are subdivided into seven families termed 5-HT1 through 5-HT7.1 The 5-HT receptor families belong to the G-protein coupled receptor superfamily with the exception of 5-HT3 receptor class which belongs to the ligand-gated ion channels.2The 5-HT1 receptor class comprises of five different receptors (5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F) which share 41-63 % overall sequence identity and couple preferentially to Gi/Go to inhibit cAMP formation.2The 5-HT1A receptor is the most widespread of all the 5-HT receptors. In the CNS, 5-HT1A receptors exist in the cerebral cortex, hippocampus, septum, amygdala and raphe nucelus in high densities, and was also demonstrated in a variety of tissues from various species.2,3 Activation of 5-HT1A receptor decreases blood pressure and heart rate, and is involved in learning, memory, relieving anxiety and depression.1,4

    Alternative names: 5HT1A Receptor (HTR1A), 5-Hydroxytryptamine receptor 1A, Serotonin receptor 1A

    Gen-ID

    24473

    NCBI Accession

    NM_000524

    UniProt

    P19327

    Pathways

    JAK-STAT Signalweg, Synaptic Membrane, Feeding Behaviour
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