KCNA3 Antikörper (Extracellular)

Produktnummer ABIN7043519

Produktdetails anti-KCNA3 Antikörper

Target: KCNA3 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3))

Bindungsspezifität: AA 263-276, Extracellular

Reaktivität: Human

Wirt: Meerschweinchen

Klonalität: Polyklonal

Konjugat: Dieser KCNA3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Verwendungszweck: A Guinea Pig Polyclonal Antibody to KV1.3 (KCNA3) Channel

Spezifität: Extracellular loop between domains S1 and S2.

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Rat,mouse - 12,14 amino acid residues identical

Produktmerkmale: Guinea pig Anti-KV1.3 (KCNA3) (extracellular) Antibody is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize KV1.3 potassium channel from mouse, rat, and human samples. The antigen used to immunize guinea pigs is the same as Anti-KV1.3 (KCNA3) (extracellular) Antibody (ABIN7043521, ABIN7044992 and ABIN7044993) raised in rabbit. Our line of guinea pig antibodies enables more flexibility with our products such as multiplex staining studies, immunoprecipitation, etc.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: KDYPASTSQDSFEA(C), corresponding to amino acid residues 263-276 of human KV1.3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100

Application Dilutions Western blot wb: 1:200

Kommentare:

Negative Control: (ABIN7236496)

Blocking Peptide: (ABIN7236496)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Details zu KCNA3

Target: KCNA3 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3))

Andere Bezeichnung: KCNA3 (KCNA3 Produkte)

Hintergrund: Potassium voltage-gated channel subfamily A member 3,KV1.3 belongs to the Shaker family of voltage-dependent K+ channels. The channel, encoded by KCNA3, is widely expressed in the brain, lung and osteoclasts and in several cell populations of hematopoietic origin. The prominence of KV1.3 channels in these cells (particularly in T lymphocytes) directed much research attention. It was found that KV1.3 is the main channel responsible for maintaining the resting potential in quiescent cells and regulating the Ca2+ signaling that is indispensable for normal T lymphocyte activation.1,2 Based on the central role of KV1.3 in regulating the initiation of an immune response, the channel has been recognized as a potential target for immunosuppressant drugs.1

Alternative names: KV1.3, Potassium voltage-gated channel subfamily A member 3

Gen-ID: 3738

NCBI Accession: NM_002232

UniProt: P22001